mordant - a substance used to treat leather or other materials before dyeing; aids in dyeing process. The kidney changes appeared a few hours after the administration and preceded changes in the liver (Franz, 1937). (c) Meglumine antimoniate (glucantime) (3): This is another preferred antimonial drug commonly used for treating cutaneous and mucocutaneous leishmaniasis. It may also be used in the preparation of novel Sb(III)-containing polyanions by reacting with trilacunary Keggin-type polyanions. The dose in cough remedies or expectorants varies from 1 to 8 mg repeated two or three times daily. The drug has also been used to treat visceral leishmaniasis and post-kala-azar dermal leishmaniasis [3,10]. (antimony potassium tartrate anlamı, antimony potassium tartrate ingilizcesi, ingilizcede antimony potassium tartrate, antimony potassium tartrate nnd) With the objective to develop new antimonials with enhanced therapeutic and safety profiles (National Schistosomiasis Research Committee, 1959), different trivalent antimonials, including tartar emetic derivatives, mercaptan antimonials, stibophen, quinoline antimony, aryl stibonate, stibinyl derivatives and antimony glycerate, were investigated for antischistosomal properties (Chu et al., 1962; Hsiao et al., 1962; Huang, 1979; National Schistosomiasis Research Committee, 1959). An elderly patient with a history of chronic heart disease had cardiac-respiratory failure and received mechanical ventilation and i.v. Thomas W. Clarkson, in Handbook of Pesticide Toxicology (Second Edition), 2001. For treating simple cutaneous lesions caused by L. aetropica a dose of 18-20 mg/kg of pentostam given twice daily for 30 days was found to be successful [17a]. Failure of the drug is attributed to irrational prescribing and misuse in this anthroponotic focus with intense transmission.95 In other parts of the world, antimonials continue to be effective. It is used as a mordant in dyeing. The drug still has some use as a diaphoretic or expectorant in certain cough syrups. The dose of tartar emetic varies greatly according to these different uses. vitamins, herbal supplements, etc. It is marketed in tablets of 600 mg. High cures may be achieved against S. japonicum in cattle by administering stibocaptate intramuscularly at a dose of 20-35 mg/kg [72,73]. 1-2H 2 O. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. Potassium tartrate is produced by the reaction of tartaric acid with potassium sodium tartrate (rochelle salt), and potassium sulfate, followed by filtration, purification, precipitation and drying. It also can be called Antimony potassium tartrate trihydrate ; and Antimonate (2-), bis (mu- (2,3-dihydroxybutanedioato (4-)-O1,O2:O3,O4))di-, dipotassium, trihydrate, stereoisomer. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations . ).Some health conditions may make you more susceptible to the side-effects of the drug. Adding anaesthesia in the syringe is of no use as the added volume increases the pain. 58 / Monday, March 26, 2012 / Rules and Regulations . Potassium antimonyl tartrate sesquihydrate, its cas register number is 28300-74-5. Potassium antimony (III) tartrate hydrate https://comptox.epa.gov/dashboard/DTXSID5049023 European Chemicals Agency (ECHA) (Iffland & Bösche, 1987). Before using Antimony Potassium Tartrate, inform your doctor about your current list of medications, over the counter products (e.g. Lower Explosive Limit (LEL): data unavailable, Upper Explosive Limit (UEL): data unavailable, Autoignition Temperature: data unavailable, Vapor Density (Relative to Air): data unavailable, National Oceanic and Atmospheric Administration, Antimony potassium tartrate trihydrate (28300-74-5). Due to extensive binding of Sb(III) to erythrocytes a complete blood exchange was performed 39 h after the poisoning, 3 L were given over 3.5 h. This late intervention was due to the blood type of the child, A1B rhe pos. Zijlstra et al. Potassium antimony tartrate (tartar emetic), sodium antimony tartrate, the thioxanthone, hycanthone, and the 5-nitrothiazole, niridazole, were formerly used in the treatment of schistosomiasis, but have been largely superseded by less toxic compounds. Despite other antischistosomiasis drugs have been developed, pentavalent Sb based drugs are still the preferred treatment of cutaneous forms of leishmaniasis http://www.cdc.gov/parasites/leishmaniasis/treatment.html 2014). ), acacia, antipyrene and mercury bichloride. Abnormalities in one or more leads included increased amplitude of P waves, a fusion of ST segment and T wave, decreased amplitude of T wave, and prolongation of the Q-T interval. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. However, a lower dose of 10 mg/kg given for 30 days has also been used, and found to exhibit almost 100% cures in children and adults suffering from visceral leishmaniasis [13a,b]. It is used in textile and leather processing and as an insecticide. fluid, and sodium polystyrene sulfonate was administered. Advanced Search | Structure Search. At this dose level, children showed 3% deaths and 7% relapses, while in adults there was 8% deaths and 5% relapses. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Get contact details & address of companies manufacturing and supplying Antimony Potassium Tartrate, 28300-74-5 across India. The chlorinated hydrocarbon tetrachloroethylene has been used since the 1920s in the treatment of hookworm infection. POTASSIUM TARTRATE (listed as Antimony), 99+%, (CAS# 28300-74-5) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Symptoms include a metallic taste, extreme nausea, copious vomiting, frequent hiccough, burning pain in the stomach, colic, frequent stools and tenesmus, fainting, bradycardia often with EGG irregularities, hypotension, difficult and irregular breathing, cutaneous anesthesia, convulsive movements, painful cramps in the legs or joints, jaundice, anuria, prostration, and death (Osol et al., 1967; AMA, 1977). Further information. In one severe acute oral poisoning, a three-year-old girl drank nearly 50 mL of a sweet tasting liquid against ants containing 2.3 g tartar emetic, several times the lethal dose for children. 3H 2 O, CAS RN; 11071-15-1] white crystalline powder with a sweetish taste It is used as a mordant or fixing agent in the leather and textile dying as well as an analytical reagent and flux additive for electoplating. Potassium Antimony Tartrate, Trihydrate Safety Data Sheet according to Federal Register / Vol. Potassium antimony tartrate is the most potent trivalent antimony compound. As urea stibamine is a complex with a non-defined structure derived from urea and p-aminophenyl stiborne acid, it is very little used in clinical practice today. When antimony potassium tartrate is rubbed on the skin in the form of an ointment, it produces little irritation at first but produces a pustular eruption if applied for long periods. Artemisinin derivatives, which are the main drugs for the treatment of malaria, extracted from the leaves of a Chinese sweet worm wood, were shown to be effective against human schistosomes. Long-term peroral exposure to high doses of antimony may also induce signs of liver toxicity. Each dose should be given 2 hr after a light meal and the patient should remain recumbent for 1 hr after treatment (AMA, 1977). It also reacts with acids, salts of heavy metals, albumins, soap and tannins. Pentostam is also used to treat cutaneous leishmaniasis at a dose of 10 mg/kg daily (maximum 600 mg/day) injected intravenously or intramuscularly for 6-10 days [11,12]. Use of antimony potassium tartrate has been abandoned as an emetic to give patients, but it is still used as an emetic to combine with certain rodenticides to make them less harmful if they are accidentally consumed by people or pets. Antimony potassium tartrate hydrate is used in the treatment of schistosomiasis. Ingestion causes gastrointestinal upset, strong irritation, vomiting. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. Shu-Hua Xiao, ... Jürg Utzinger, in Advances in Parasitology, 2010. MDL number MFCD00167056. In Sudan it costs 40 US cents per tablet, this is mainly due to new manufacturers in Korea, China, Egypt, Sudan, Brazil, and other countries. Rats given 6 mg antimony per kg body weight in drinking water for 6, 8, or 12 weeks showed increased levels of blood urea, serum creatinine, and serum sodium and potassium. Molecular Weight 667.87 . (1980) described a case of possible pentavalent antimony poisoning. 9.2C) (Huang, 1979; Wang et al., 1985; Yan et al., 1985), revealed high efficacy and good tolerance in clinical trials (Table 1). In subacute cases, fatty degeneration of the liver, kidney, and heart may be present; degenerative changes in the nervous system are less common. 58 / Monday, March 26, 2012 / Rules and Regulations 07/22/2020 EN (English US) 6/8 Potassium Antimony Tartrate, Trihydrate (28300-74-5) ErC50 (algae) 206 mg/l (OECD 201: Alga, Growth Inhibition Test, 72 h, Pseudokirchneriella subcapitata, ).Some health conditions may make you more susceptible to the side-effects of the drug. Contents. China for several years. It has been reported that a 40 days regime of 20 mg/kg is more effective than the 20 day or 30 day schedules. 1-2H 2 O. This has led to its use also in control of schistosomiasis using mass chemotherapy. Compound is more effective in treating poisoning by antimony potassium tartrate, 28300-74-5 manufacturers, suppliers & in. The accidental ingestion of pesticides glucantime is available as a powerful emetic safer! After the administration and preceded changes in the treatment of kala-azar in India those of acute tartrate. Aid measures and others should be known mg/kg is more stable in rodenticide than... Indicates that no RQ is assigned to this generic or broad class, although the class is compound... H after admission or irritation ) develop the mainstay of antischistosomal treatment pregnancy. 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