The effects of antimony and its compounds on human and environmental health differ widely. Chronic exposure can lead to; antimony pneumonia, alterations in lung function, chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation. Poisoning caused by ingestion of antimony. Fischer 344 rats were exposed by inhalation to Sb2O3 (antimony trioxide) dust at exposure levels of 0, 0.25, 1.08, 4.92, and 23.46 mg/m3 for 6 hr/day, 5 days/week for 13 weeks followed by a 27-week observation period. Hazard Summary. Inhalation studies with respirable antimony trioxide … The guidelines for maximum permissible levels of antimony in drinking water are as follows: Remove the individual from the toxic environment. Despite the fact that large doses work as an emetic, if left untreated, a person may die. OSHA, IARC, and NTP do not classify antimony trioxide as a carcinogen. Acute (short-term) exposure to antimony by inhalation in humans results in effects on the skin and eyes. 0000012712 00000 n 0000002501 00000 n 0000000016 00000 n A silt-loam soil (pH 7.0, background 0.005 mmol Sb kg−1) was amended with Sb2O3at various concentrations. Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. Toxicity can also result from repeated exposure to antimony in medications, such as tartar emetic (antimony and potassium tartrate), used to induce vomiting and in treatment of helminthic and fungal infestations. It is a rare element, but can sometimes be found naturally, mainly as sulfide mineral stibnite. The oxides of arsenic, antimony, and bismuth are comparable in their toxicity, but their volatilities differ widely. Additionally, such individuals also suffer from hair loss and develop a scaly skin rash that called lichen planus. Immediate steps should be taken to limit its spread to the environment. : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. Inhalation of antimony trioxide (and similar poorly soluble Sb(III) dust particles such as antimony dust) is considered harmful and suspected of causing cancer. These alloys are used in lead storage batteries, solder, sheet and pipe metal, bearings, castings, type metal, ammunition, and pewter. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardiotoxicity. We hope you find the information helpful in your journey to healing! A silt-loam soil (pH 7.0, background 0.005 mmol Sb kg−1) was amended with Sb2O3 at various concentrations. 0 Liver: USG Abdomen / Liver biopsy as clinically indicated to rule out internal damage. 0000000796 00000 n The industrial use of antimony has not appeared to be … Magnesium or selenium deficiency increase antimony absorption and retention in the body. Identification Product Name Antimony(III) oxide Cat No. However, the effects will vary depending upon the amount and period of exposure. In accordance with the diantimony trioxide CSR, the NOAEL of 1686 mg/kg bw/d from a subchronic oral toxicity study in rats is selected as being the most relevant for estimating systemic effects that might be associated with dermal uptake of antimony metal or antimony (III) compounds. 0000007003 00000 n %%EOF 0000001502 00000 n If the problem has been caused through the inhalation, ensure that the individual has fresh air to breathe.Â. CAS number: 7440-36-0 (Metal) NIOSH REL: 0.5 mg Sb/m3 TWA Current OSHA PEL: 0.5 mg Sb/m3 TWA 1989 OSHA PEL: Same as current PEL 1993-1994 ACGIH TLV: 0.5 mg Sb/m3 TWA Description of substance: Varies Original (SCP) IDLH: 80 mg Sb/m3 Basis for original (SCP) IDLH: AIHA [1959] reported that the severity of hazard is moderate to high for both acute and chronic exposures to antimony … Little antimony is currently mined in the United States. Elemental antimony metal does not affect human and environmental health. x�b```�\V�� ��ea��������8��"PԌ�����Ɩ…g �L,� k�x��R��\P�Ł�����5 j� �n )��Ȟ�ŀX�D���Q�Ƀ�C���!��C�X�цx���f!�S<7D*�)p��5XB��H3�-�8F� ���@� � "� IRIS assessment development process. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. It is insoluble in water. Antimony trioxide is known to pass into breast milk and to transverse the placenta only in very small amounts. <]>> Includes washing the stomach with sterile or saltwater to remove poison. It is for educational purposes only. The fate and toxicity of this poorly soluble compound in soil is insufficiently known. It can also be found in foods such as meats, vegetables, seafood and tobacco. endstream endobj 35 0 obj <>stream H��T]o�0}ϯ��I������-�2��QWk7�! Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Everyone is exposed to low levels of antimony in the environment. ACGIH (2006) classified “antimony trioxide production” as a suspected human carcinogen (Group A2), although “antimony and compounds” was not similarly classified. In addition antimony trioxide is possibly carcinogenic to humans. 0000001060 00000 n This site is a comprehensive resource for information regarding heavy metal toxicity and chelation therapy. Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. : Antimony trioxide . It accounts for 80% of total antimony in the USA used in the manufacturing of various consumer products.1 Human exposure to antimony trioxide occurs through ambient air, consumer products and workplace settings.1 2 In consumer products, it is commonly … Antimony is usually mixed with other metals such as lead and zinc to form mixtures of metals called alloys. Copyright © 2021 | WordPress Theme by MH Themes, Protocol for IV and Oral EDTA Chelation – Medical Review, FDA Public Health Advisory: Edetate Disodium, Antimony accumulates in adrenals, thyroid, kidney, liver, spleen, and bone, Binds to the good sulfhydryl detoxification chemicals groups. Those who are exposed to low doses for over long periods of time, will also show the symptoms of poisoning as mentioned above. The information is not presented with the intention to treat or diagnose any disease or condition. Breathing air contaminated with antimony can cause eye and lung irritation, heart and lung damage, stomach pains, diarrhea, vomiting, and stomach ulcers. �$�*���� �-F�|~9���sƄ�S}�[����Ɯ�(���yNz\F$>&���X&���gXd$8��p4���+7Z��6l[7��$\\����}[�۹���S%�n����Iġ���ݦ�)��jz�ߨU��J0�w������6�E�V$�������W����[��_]�ҁ? It is insoluble in water. The primary hazard is the threat to the environment. Carcinogenicity ACGIH classifies antimony trioxide as TLV-A2 suspected human carcinogen. One compound—antimony trioxide—is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. The effects are hypothesized to be attributed to inhalation of poorly solubl… Disclaimer: We are not medical doctors. Symptoms of Excessive Antimony Exposure and Antimony Toxicity. Antimony trioxide is used in the production of polyethylene terephthalate (PET) water bottles. Skin sensitising (Ss) – Recognised skin sensitiser: comes from a harmonised C&L classifying the substance as Skin Sens. Chelation therapy with BAL, DMSA, or DMPS has been shown to improve antimony toxicity. The oxides of arsenic, antimony, and bismuth are comparable in their toxicity, but their volatilities differ widely. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. Its TLV is 0.5 mg/m , as for most antimony compounds. Antimony trioxide is classified as a carcinogen in the state of California. SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. Chelation 0000003037 00000 n July 5, 2018 Antimony Toxicity Most commonly, the metal is used as a flame retardant in products as diverse as toys, car seat covers, engine covers for light aircraft, clothing for kids, and uniforms for fire fighters. Antimony trioxide is a white crystalline solid. 0000001321 00000 n * Exposure to Antimony Trioxidecan irritate the nose, mouth, throat and lungs causing cough, wheezing and/or shortness of breath. Antimony is a silvery-white metal that is found in the earth's crust. * Antimony Trioxidecan cause headaches, poor appetite, nausea, vomiting, dry throat, and loss of sleep. More than 70% of Sb in soil solution was present as Sb(V) (antimonate) within 2 days. Subsequently, an inhalation oncogenicity study was conducted at exposure levels of … 0000012811 00000 n 0000002788 00000 n Sections I (Health … Antimony trioxide is a white crystalline solid. Chronic poisoning by antimony trioxide is also rare. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. (IARC) (1989) concluded that antimony trioxide is possibly carcinogenic to humans (Group 2B), based on sufficient evidence in animals and inadequate evidence in humans. Antimony trioxide has suspected carcinogenic potential for humans. Zd> Antimony is a silvery grey metalloid. However, these effects are only observed with female rats and after long-term exposure to high dust concentrations. 0000001994 00000 n More information about reproductive toxicity here. It is brought into this country from other countries for processing. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. Introduction. 0000006312 00000 n TRADEASIA INTERNATIONAL PTE LTD 133 Cecil Street # 12-03 Keck Seng Tower, Singapore 069535, Antimony trioxide is considered possibly carcinogenic to humans (Group 2B) by the IARC [150] and was recently listed as reasonably anticipated to be a human carcinogen by the NTP [151]. 0000005517 00000 n Exposure to antimony trioxide may increase the risk of cancer. 0. Always consult with your doctor before making any decision affecting your health. No other human health hazards were identified for antimony(III) oxide, and no risks to human health and the environment were identified from the production and use of antimony trioxide in daily life. Antimony spots (from vapor) Scaly Skin, Chickenpox, Blisters; Diarrhea, Vomiting, Digestive Upset; Hypovolemic Shock; Eye and eye lid inflammation (Conjuctivitis, , Keratitis) Chronic exposure can lead to; antimony pneumonia, alterations in lung function, chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural … 0000008472 00000 n 0000002466 00000 n Gastrointestinal toxicity Ingestion of a substantial quantity of antimony trioxide may result in nausea, vomiting and diarrhoea. Symptoms include an acrid metallic taste, cardiac failure, sweating, and vomiting about 30 min after ingestion. Antimony toxicity occurs either due to occupational exposure or during therapy. Antimony trioxide TSCA 8(b) inventory: Antimony trioxide SARA 313 toxic chemical notification and release reporting: Antimony trioxide CERCLA: Hazardous substances. The main signs are irritation of the respiratory tract and of the skin and a characteristic pneumoconiosis, which is visible on chest X-rays. Antimony trioxide is a high-production-volume, inorganic chemical that is produced from the metalloid element antimony. 23 0 obj <> endobj startxref 47 0 obj <>stream Antimony Review Pulmonary Toxicity Cancer Genotoxicity Mechanism ABSTRACT Although occupational exposure to antimony and its compounds can produce pulmonary toxicity, human car-cinogenic impacts have not been observed. d_AO� (!�R�6Ni��r�r=���;Ћ��v:����EJ"���aJĢY���c3��0��S2� �� D1�!�W�K��������Bƒ72A�P�P����E�G�ء��z�R+鱔Ţ1#���d�I�--�V}�L`�ʾ��b�7�Y��;:��T��AOZw������'���*�;�z���� �J8ʨ�m�]�'���v{�a��"�UQCq_�vph��)kX�e�۔k����)%Jb'�u�Ⱥ�_iGm��v(dL�{�Q*k�#q+ C��ި�m���@�kX��)����� %PDF-1.4 %���� Another risk group for antimony exposure are patients suffering from schistosomiasis and leishmaniasis. 0000010019 00000 n Antimony trioxide has suspected carcinogenic potential for humans. 0000006747 00000 n 0000007824 00000 n Antimony trioxide is on the Proposition 65 list because it can cause cancer. Antimony toxicity occurs either due to occupational exposure or during therapy. xref [ … Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardio toxicity. 23 25 0000003918 00000 n In long-term animal experiments, rats exposed to antimony trioxide via inhalation showed a high frequency of lung tumours. @ZؖdK@-�~�v�Z�J{XQ���=>��c�_^3x��^$$IP��)a *R$ᰪ��i�`�x���;ך}�1J(�9.�bj@\�-�G����|=z>��F��$��T�m�~�BȈ��0S!��I��OM�W���o��I"����!�@��/p�$���.0���?� Antimony(III) oxide has suspected carcinogenic potential for humans. * Prolonged or repeated contact can cause ulcers or sores in the nose. Over fifty people were "very sick" and treated in hospital after drinking lemonade contaminated with 13 mg/L antimony. A second group of people at risk for antimony exposure is patients suffering from schistosomiasis and leishmaniasis. Adequate magnesium, selenium, and methionine decrease the absorption and retention of antimony. 0000003114 00000 n 0000001141 00000 n High blood pressure, muscle break down, heart pain, Stomach and intestinal disorders (Fatigue, Gingivitis, Stomatitis), World Health Organization (WHO): 20 micrograms per liter (ug/L), S. EPA, Health Canada, and the Ontario Ministry of Environment: 6 ug/L, German Federal Ministry of Environment: 5 ug/L, Blood Tests (Complete Blood Count, Blood Antimony Level) : Blood Antimony level should be less than 6 mg/dl, Urine Test : Urine Antimony level 1ml / liter. Occupational exposure of Antimony includes individuals working with brake pad systems for heavy weight vehicles and port workers who are exposed to traffic on a daily basis. Large doses cause vomiting, diarrhea, abdominal discomfort and tingling of the extremities. trailer Low doses cause headaches, nausea, dizziness and depression. 0000009329 00000 n ; Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. Sudden infant death syndrome (SIDS) has also been found to be associated with antimony poisoning. The fate and toxicity of this poorly soluble compound in soil is insufficiently known. The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. The toxicity of antimony trioxide is topical because it is a likely byproduct of the combustion of some materials "fireproofed" with antimony compounds. Antimony trioxide; CASRN 1309-64-4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. In addition antimony trioxide is possibly carcinogenic to humans. 0000004671 00000 n H��TMs�0��W�:FA3M;��N�[�dC� �����$ۉ'�dzAB���{oi�-.�&�z!Oe)4W��iM�`"Msh7��8wf|���q�t��q���+V����W�Յ�xh�'�U���5̽?���_�8au���r$. 0000002545 00000 n 1, 1A, or 1B. Antimony trioxide is both a systemic poison and a skin disease hazard, although its toxicity is three times less than that of the metal. In large doses it causes irritation of the lining of the alimentary tract, resembling arsenic poisoning. The metal and its compounds can be toxic. endstream endobj 24 0 obj <> endobj 25 0 obj <> endobj 26 0 obj <>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/ExtGState<>>> endobj 27 0 obj <> endobj 28 0 obj <> endobj 29 0 obj [/ICCBased 44 0 R] endobj 30 0 obj [/Indexed 29 0 R 15 45 0 R] endobj 31 0 obj <> endobj 32 0 obj <> endobj 33 0 obj <> endobj 34 0 obj <>stream Subchronic and chronic inhalation studies with rats and mice have demonstrated increased incidence of lung neoplasia following antimony trioxide exposure. are not met since there is an absence of consistent identifiable toxic effects other than the non-specific PSP overload, which is an adaptive response not triggering a STOT classification. Eye and eye lid inflammation (Conjuctivitis, , Keratitis). Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. 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Lining of the extremities then mixed with other metals to form antimony.., cardiac failure, sweating, and NTP do not classify antimony trioxide is in. * Prolonged or repeated contact can cause cancer regarding heavy metal toxicity and chelation with. Is 0.5 mg/m, as for most antimony compounds is on the skin and a pneumoconiosis... And NTP do not classify antimony trioxide exposure humans results in effects on the skin and eyes,! Mice have demonstrated increased incidence of antimony toxicity in the workplace pneumoconiosis, antimony, bismuth! Adams-Stokes syndrome drinking lemonade contaminated with 13 mg/L antimony the amount and period of.. Antimonyâ absorption and retention of antimony in the United States always consult your.